Research Article
Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise
Table 3
Impact scores for metabolic pathways in CFS.
| | Time | Pathway Name | Total | Hits | | | Holm | FDR | Impact score | Ranking |
| | Before exercise | TCA cycle | 20 | 1 | 0.134 | 2.008 | 1.00 | 1.00 | 0.068 | 1 | | Alanine, aspartate and glutamate metabolism | 24 | 1 | 0.159 | 1.839 | 1.00 | 1.00 | 0.063 | 2 | | Steroid hormone biosynthesis | 70 | 1 | 0.402 | 0.912 | 1.00 | 1.00 | 0.015 | 3 | | Purine metabolism | 68 | 1 | 0.393 | 0.935 | 1.00 | 1.00 | 0.003 | — | | D-Glutamine and D-glutamate metabolism | 5 | 1 | 0.035 | 3.347 | 1.00 | 1.00 | 0.000 | — | | beta-Alanine metabolism | 19 | 1 | 0.128 | 2.056 | 1.00 | 1.00 | 0.000 | — | | Propanoate metabolism | 20 | 1 | 0.134 | 2.008 | 1.00 | 1.00 | 0.000 | — | | Butanoate metabolism | 20 | 1 | 0.134 | 2.008 | 1.00 | 1.00 | 0.000 | — | | Tryptophan metabolism | 41 | 1 | 0.258 | 1.357 | 1.00 | 1.00 | 0.000 | — |
| | After exercise | TCA cycle | 20 | 3 | 0.000 | 8.181 | 0.02 | 0.02 | 0.140 | 1 | | Alanine, aspartate, and glutamate metabolism | 24 | 2 | 0.012 | 4.454 | 0.93 | 0.47 | 0.067 | 2 | | Sphingolipid metabolism | 21 | 1 | 0.141 | 1.963 | 1.00 | 1.00 | 0.053 | 3 | | Steroid hormone biosynthesis | 70 | 1 | 0.402 | 0.912 | 1.00 | 1.00 | 0.015 | 4 | | D-Glutamine and D-glutamate metabolism | 5 | 1 | 0.035 | 3.347 | 1.00 | 0.95 | 0.000 | — | | Glyoxylate and dicarboxylate metabolism | 16 | 1 | 0.109 | 2.219 | 1.00 | 1.00 | 0.000 | — | | Butanoate metabolism | 20 | 1 | 0.134 | 2.008 | 1.00 | 1.00 | 0.000 | — | | Pyruvate metabolism | 22 | 1 | 0.147 | 1.919 | 1.00 | 1.00 | 0.000 | — | | Fatty acid elongation in mitochondria | 27 | 1 | 0.177 | 1.730 | 1.00 | 1.00 | 0.000 | — | | Fatty acid metabolism | 39 | 1 | 0.247 | 1.400 | 1.00 | 1.00 | 0.000 | — | | Tyrosine metabolism | 42 | 1 | 0.263 | 1.336 | 1.00 | 1.00 | 0.000 | — | | Biosynthesis of unsaturated fatty acids | 42 | 1 | 0.263 | 1.336 | 1.00 | 1.00 | 0.000 | — | | Fatty acid biosynthesis | 43 | 1 | 0.268 | 1.315 | 1.00 | 1.00 | 0.000 | — | | Arginine and proline metabolism | 44 | 1 | 0.274 | 1.295 | 1.00 | 1.00 | 0.000 | — |
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of the impact score >0.01.
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