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BioMed Research International
Volume 2017 (2017), Article ID 8215392, 8 pages
https://doi.org/10.1155/2017/8215392
Research Article

Ameliorative Effect of Cactus (Opuntia ficus indica) Extract on Lithium-Induced Nephrocardiotoxicity: A Biochemical and Histopathological Study

1Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, University of Gafsa, 2112 Gafsa, Tunisia
2Research Unit of Active Biomolecules Valorisation, Higher Institute of Applied Biology of Medenine (ISBAM), University of Gabes, 4119 Medenine, Tunisia
3Unit of Common Services, Faculty of Sciences of Gafsa, University of Gafsa, 2112 Gafsa, Tunisia
4Higher Institute of Applied Biology of Medenine (ISBAM), University of Gabes, 4119 Medenine, Tunisia

Correspondence should be addressed to Anouar ben Saad; moc.liamg@57daasrauona

Received 16 August 2017; Revised 8 October 2017; Accepted 15 October 2017; Published 10 December 2017

Academic Editor: Kazim Husain

Copyright © 2017 Anouar ben Saad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Opuntia ficus indica (family Cactaceae) is used in the treatment of a variety of conditions including metal-induced toxicity. The study reports the protective effects of Opuntia ficus indica (CCE) against lithium carbonate-induced toxicity in rats. Nephrocardiotoxicity was induced in male Wistar rats by single dose of lithium carbonate (25 mg/kg b.w twice daily for 30 days). Aqueous extract of Opuntia ficus indica was administered at the dose of 100 mg/kg of b.w by gavage for 60 days. Obtained results revealed that administration of lithium carbonate caused a significant increase in serum creatinine, uric acid, and urea levels. Additionally, a significant decrease in the level of renal and cardiac SOD, CAT, and GPx activities was associated with a significant increase of MDA levels in lithium carbonate group more than those of the control. However, the treatment of experimental rats with CCE prevented these alterations and maintained the antioxidant status. The histopathological observations supported the biochemical evidences of nephrocardioprotection. CCE supplementation could protect against lithium carbonate-induced renal and cardiac injuries in rats, plausibly by the upregulation of antioxidant enzymes and inhibition of MDA to confer the protective effect.