Latent Class Analysis of Noninvasive Methods and Liver Biopsy in Chronic Hepatitis C: An Approach without a Gold Standard

Table 1

Baseline characteristics of included patients.

	Patients ()
Male gender	40 (34)
Age, years	55 [48–62]
BMI, kg/m^2	26 [24–30]
ALT, U/L	57 [38–110]
AST, U/L	49 [34–81]
Alkaline phosphatases, U/L	76 [62–99]
GGT, U/L	67 [37–129]
Platelets, ×10^9/L	212 [174–260]
Noninvasive methods
Transient elastography, kPa	8.3 [6.4–13.6]
,  kPa	65 (56)
,  kPa	30 (26)
APRI	0.68 [0.43–1.37]
,	27 (23)
,	18 (15)
ELF	9.39 [8.70–10.49]
,	59 (50)
,	36 (31)
Liver biopsy
Specimen length, mm	20 [10–30]
Portal tracts,	10 [8–12]
Fibrosis, METAVIR
	63 (54)
	35 (30)
	11 (9)
	8 (7)

Data expressed as median [interquartile range] or absolute (%). ALT, alanine transaminase; APRI, aspartate-to-platelet-ratio-index; AST, aspartate transaminase; BMI, body mass index; ELF, enhanced liver fibrosis; GGT, gamma-glutamyltransferase; TE, transient elastography. Castéra et al. [19], Wai et al. [20], and Fernandes et al. [21] cut-offs were used for fibrosis staging based on transient elastography, APRI, and ELF, respectively.