Neutrophil Extracellular Traps Are Pathogenic in Ventilator-Induced Lung Injury and Partially Dependent on TLR4

Figure 7

Toll-like receptor 4 knockout prevents the development of lung injury (B). (a) Low (magnification 200x, scale bar = 40 μm) power views of the lungs of spontaneous ventilation, protective ventilation, and injurious ventilation in the TLR4 WT mice and the TLR4 KO mice, respectively. Hematoxylin and eosin stain. The TLR4 KO mice have less inflammatory cell infiltration, alveolar septal thickening, pulmonary edema, and hemorrhage than the TLR4 WT mice during HTV. (b) The lung injury score in the TLR4 KO HTV group was significantly lower than those in the TLR4 WT HTV group. Two-way ANOVA indicated that only ventilation was significant (P>0.05), but analyzing TLR4 WT HTV and TLR4 KO HTV with Student’s t-test indicated a statistical significance ( > 0.05). .

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