Research Article

Role of P-Glycoprotein Inhibitors in the Bioavailability Enhancement of Solid Dispersion of Darunavir

Table 4

Apparent permeability coefficients (cm/s). Data presented as mean ± SD, for each formulation.

Formulation codeEquation of graph between drug conc. inside sac (µg/ml) and time (sec)Apparent permeability coefficient
(×10−6 cm/sec)
mean ± SD

Drug
Drug + Ritonavir
SD7

SD7 = (DRV : Kolliphor TPGS = 1 : 2 w/w, spray drying).