Role of P-Glycoprotein Inhibitors in the Bioavailability Enhancement of Solid Dispersion of Darunavir

Table 5

Results for various pharmacokinetic parameters by different formulations in Wistar rats. Data presented as mean ± SD, for each formulation.

Groups	Formulations	Pharmacokinetic parameters
		(ng/ml)	(h)	(ng⋅min/ml)	(ng⋅min/ml)
Group A (fasted)	DRV		1
	DRV + RTV		1
	SD7		1
Group B (fed)	DAR		1
	DRV + RTV		1
	SD7		1

( = peak plasma concentration; = time taken to reach ; = area under curve from 0-; = area under curve from 0-α; = elimination rate constant).