BioMed Research International / 2017 / Article / Tab 5

Research Article

Role of P-Glycoprotein Inhibitors in the Bioavailability Enhancement of Solid Dispersion of Darunavir

Table 5

Results for various pharmacokinetic parameters by different formulations in Wistar rats. Data presented as mean ± SD, for each formulation.

GroupsFormulationsPharmacokinetic parameters
 (ng/ml) (h) (ng⋅min/ml) (ng⋅min/ml)

Group A (fasted)DRV1
DRV + RTV1
SD71

Group B (fed)DAR1
DRV + RTV1
SD71

( = peak plasma concentration; = time taken to reach ; = area under curve from 0-; = area under curve from 0-α; = elimination rate constant).

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