Triclocarban and Triclosan Inhibit Human Aromatase via Different Mechanisms

Figure 7

Docking of triclosan to human CYP19A1. The crystal structure of recombinant human CYP19A1 (PDB ID: 4KQ8) with heme and androstenedione was docked. It shows the binding of triclosan to the steroid-binding site of CYP19A1 similar to testosterone. Left green is heme structure; right green is testosterone structure; and the sky blue is triclosan, which exactly matches the testosterone-binding site.