Plant Proteinase Inhibitor BbCI Modulates Lung Inflammatory Responses and Mechanic and Remodeling Alterations Induced by Elastase in Mice

Table 2

Effect of BbCI treatment on positive cells in airway walls of all groups. Data are presented as mean ± SE. ELA group had greater values than control groups (SAL and SALBC) in all airway walls parameters. The group that was treated with BbCI inhibitor (ELABC) had attenuated this response in neutrophils, TNFα, collagen fibers, elastic fibers, MMP-9- and MMP-12-positive cells, and iNOS-positive cells. compared to SAL and SALBC groups. compared to ELA group.

Airway walls
Inflammatory response	SAL	ELA	SALBC	ELABC
Neutrophils (cells/10^4 μm^2)	2.77 ± 0.3		5.03 ± 0.4
TNFα (cells/10^4 μm^2)	2.58 ± 0.4		2.92 ± 0.3
Remodelling response	SAL	ELA	SALBC	ELABC
Collagen fibers (%)	5.55 ± 0.1		5.61 ± 0.1
Elastic fibers (%)	0.81 ± 0.1		1.08 ± 0.0
MMP-9-positive cells/10^4 μm^2	2.07 ± 0.4		4.63 ± 0.8
MMP-12-positive cells/10^4 μm^2	3.14 ± 0.3		4.13 ± 0.2
TIMP-1-positive cells/10^4 μm^2	2.96 ± 0.2		2.85 ± 0.6
Oxidative stress response	SAL	ELA	SALBC	ELABC
iNOS-positive cells/10^4 μm^2	5.35 ± 0.5		6.24 ± 0.7
eNOS-positive cells/10^4 μm^2	3.20 ± 0.2		3.80 ± 0.3	7.96 ± 0.4
8-iso-PGF2α-positive cells/10^4 μm^2	5.91 ± 0.8		7.65 ± 0.5