Research Article

Upregulation of Mitf by Phenolic Compounds-Rich Cymbopogon schoenanthus Treatment Promotes Melanogenesis in B16 Melanoma Cells and Human Epidermal Melanocytes

Table 2

Top ten (10) genes differentially downregulated in B16 cells following treatment with Cymbopogon schoenanthus (CYM) ethanol extract (control versus CYM).

Gene symbolGene nameMolecular functionBiological functionFold change

Nadk2NAD kinase 2, mitochondrialATP BindingMetabolic process; NAD/NADP metabolic process; phosphorylation

Fam21Family with sequence similarity 21Phosphatidylinositol-3,4,5-trisphosphate bindingProtein transport

RimklaRibosomal modification protein rimK-like family member AATP binding; Catalytic activityCellular protein modification process

PkigProtein kinase inhibitor, gammacAMP-dependent protein kinase inhibitor activityNegative regulation of cAMP-dependent protein kinase activity; signal transduction

Zg16Zymogen granule protein 16Carbohydrate bindingProtein transport

Zfp60Zinc finger protein 60DNA binding; metal ion binding; nucleic acid binding; transcription factor activity, sequence-specific DNA bindingRegulation of transcription, DNA-templated

Col12a1Collagen, type XII, alpha 1ā€‰Cell adhesion

Ccdc171coiled-coil domain containing 171ā€‰Sequence-specific DNA binding transcription factor activity

Nanos1Nanos homolog 1 (drosophila)Zinc ion binding; RNA bindingPositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; epithelial cell migration

Crklv-crk sarcoma virus CT10 oncogene homolog-like (avian)RNA bindingCell differentiation, cellular component organization, cell proliferation