Integrative Analysis of miRNA and mRNA Expression Profiles in Calcium Oxalate Nephrolithiasis Rat Model

Table 3

Representative GO terms of the predicted miRNAs targets.

GO ID	GO term	Target genes	value
Upregulated miRNAs
GO:0055114	Oxidation reduction	ME1, BCKDHA, LDHC, SUOX, GPD1, ADHFE1, CYP1A1, HSD3B6, GLUD1, CYCS, HGD, GCLM, HIBADH, ACOX3, FDFT1, IVD, DHCR7, HSD11B1, AKR7A3, DMGDH, MECR, ALDH9A1, NQO2
GO:0009725	Response to hormone stimulus	ME1, BCKDHA, AR, CRYAB, STAT5A, GGH, AQP1, PPARGC1B, GHRHR, PRSS8, EIF4EBP2, WFDC1, GHRL, TGFBR3, GHR, GNG7
GO:0006811	Ion transport	SLC36A1, SLC38A3, CASR, FXYD4, AQP1, FXYD6, BSND, SLC23A1, ATP6V0E2, P2RY4, ATP6V1E1, SLC39A8, SCN4B, SLC13A2, PLLP, SLC5A6, SLC4A1, ATP6V0D1	0.00018
Downregulated miRNAs
GO:0009611	Response to wounding	CXCL1, MASP1, SCN3A, TACR1, CCR1, CXCL2, GJA1, TLR4, CCL7, TGFB2, TIMP1, VCAM1, PCSK1, CASP3, FGG, CD44, SERPINE1, IL1B, REG3G, KLF6, TNFSF4, LYN, MAP1B, IL1RN, C4BPA, IL24, P2RY12, FCGR2B, F3, CCR2, NPPB, IGFBP1, PTAFR, IGFBP4
GO:0006954	Inflammatory response	CXCL1, TNFSF4, LYN, MASP1, TACR1, CCR1, IL1RN, CXCL2, TLR4, C4BPA, CCL7, VCAM1, FGG, CD44, FCGR2B, F3, CCR2, IL1B, NPPB, REG3G, PTAFR, IGFBP4
GO:0006952	Defense response	CXCL1, MASP1, FGR, GRIK2, TACR1, CCR1, CXCL2, TLR4, CCL7, VCAM1, FGG, CD44, IL1B, REG3G, PTPRC, TNFSF4, LYN, IL1RN, C4BPA, FCGR2B, F3, CCR2, NPPB, PTAFR, IGFBP4