Integrative Analysis of miRNA and mRNA Expression Profiles in Calcium Oxalate Nephrolithiasis Rat Model

Table 4

KEGG pathway analysis of the predicted miRNAs targets.

KEGG pathway term	Target genes	value
rno00280: valine, leucine, isoleucine degradation	BCKDHA, MCCC2, IVD, ECHS1, ACAT1, HIBADH, ALDH9A1	0.0018
rno04060: cytokine-cytokine receptor interaction	CCL22, CNTF, TNFSF4, IL9R, TNFRSF12A, CLCF1, CCR1, CXCL2, CCR2, IL21R, IL1B, FAS, GHR	0.010
rno04115: p53 signaling pathway	CASP3, CDKN1A, RRM2, CASP8, CYCS, SERPINE1, FAS	0.011
rno04540: gap junction	TUBB2B, TUBB5, GJA1, GUCY1A3, GUCY1B3, HTR2B, TUBB3	0.027
rno00380: tryptophan metabolism	CCBL1, CYP1A1, ECHS1, ACAT1, ALDH9A1	0.033
rno04080: neuroactive ligand-receptor interaction	ADORA2B, GRIK2, TACR1, GRIA3, GHRHR, P2RY4, SSTR1, CNR1, P2RY2, CCR2, HTR2B, PTAFR, ADRA1D, GHR	0.035