Table of Contents Author Guidelines Submit a Manuscript
Table of Contents Alerts

To receive news and publication updates for BioMed Research International, enter your email address in the box below.

BioMed Research International
Volume 2017, Article ID 8314276, 9 pages
https://doi.org/10.1155/2017/8314276
Research Article

Simvastatin Ameliorates PAK4 Inhibitor-Induced Gut and Lung Injury

Shuming Pan,1 Zengbin Wu,1 Xuan Liu,1 Jiameng Chen,1 Huiqi Wang,1 Dan Liu,2 Aihua Fei,1 Liang Chen,1 and Chengjin Gao1

1Emergency Department, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
2Emergency Department, Shanghai Tenth People’s Hospital, Shanghai 200072, China

Correspondence should be addressed to Chengjin Gao; moc.361@3002oagnijgnehc

Received 30 July 2017; Accepted 29 November 2017; Published 28 December 2017

Academic Editor: Anjali Joshi

Copyright © 2017 Shuming Pan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. E. Gill, M. Rohan, and S. Mehta, “Role of pulmonary microvascular endothelial cell apoptosis in murine sepsis-induced lung injury in vivo,” Respiratory Research, vol. 16, no. 1, article 109, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. Hirano, M. Aziz, W.-L. Yang et al., “Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury,” Critical Care, vol. 19, no. 1, article no. 53, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Li, W. Han, V. Polosukhin et al., “NF-κB inhibition after cecal ligation and puncture reduces sepsis-associated lung injury without altering bacterial host defense,” Mediators of Inflammation, vol. 2013, Article ID 503213, 9 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Yu, L. Jing, X. Zhang, and C. Gao, “Simvastatin attenuates acute lung injury via regulating Cdc42-PAK4 and endothelial microparticles,” Shock, vol. 47, no. 3, pp. 378–384, 2017. View at Google Scholar
  5. Y. F. Wang, “Endothelium-derived 5-Methoxytryptophan is a circulating anti-inflammatory molecule that blocks systemic inflammation,” Circulation Research, vol. 119, pp. 222–236, 2016. View at Google Scholar
  6. S. Matsuo, W. Yang, M. Aziz, A. Jacob, and P. Wang, “Cyclic arginine-glycine-aspartate attenuates acute lung injury in mice after intestinal ischemia/reperfusion,” Critical Care, vol. 17, no. 1, article R19, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. E. A. Deitch, “Gut-origin sepsis: evolution of a concept,” The Surgeon, vol. 10, no. 6, pp. 350–356, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. S. M. Sharpe, X. Qin, Q. Lu et al., “Loss of the intestinal mucus layer in the normal rat causes gut injury but not toxic mesenteric lymph nor lung injury,” Shock, vol. 34, no. 5, pp. 475–481, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. Z. Zhou and Z. You, “Mesenchymal stem cells alleviate LPS-induced acute lung injury in mice by MiR-142a-5p-controlled pulmonary endothelial cell autophagy,” Cellular Physiology and Biochemistry, vol. 38, no. 1, pp. 258–266, 2016. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Kohama, H. Yamashita, M. Aoyama-Ishikawa et al., “Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation,” Surgery, vol. 158, no. 2, pp. 399–407, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Tian, G. Gawlak, J. J. O'Donnell, A. A. Birukova, and K. G. Birukov, “Activation of vascular endothelial growth factor VEGF-receptor-2 mediates endothelial permeability caused by cyclic stretch,” The Journal of Biological Chemistry, vol. 291, no. 19, pp. 10032–10045, 2016. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Gao, R. Li, Y. Liu, L. Ma, and S. Wang, “Rho-kinase-dependent F-actin rearrangement is involved in the release of endothelial microparticles during IFN-α-induced endothelial cell apoptosis,” The Journal of Trauma and Acute Care Surgery, vol. 73, no. 5, pp. 1152–1160, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. C. M. Wells, A. D. Whale, M. Parsons, J. R. W. Masters, and G. E. Jones, “PAK4: A pluripotent kinase that regulates prostate cancer cell adhesion,” Journal of Cell Science, vol. 123, no. 10, pp. 1663–1673, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. J. R. Jacobson, S. M. Dudek, K. G. Birukov et al., “Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin,” American Journal of Respiratory Cell and Molecular Biology, vol. 30, no. 5, pp. 662–670, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. A. John-Baptiste, W. Huang, E. Kindt et al., “Evaluation of potential gastrointestinal biomarkers in a PAK4 inhibitor-treated preclinical toxicity model to address unmonitorable gastrointestinal toxicity,” Toxicologic Pathology, vol. 40, no. 3, pp. 482–490, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. C. E. Lagoa, Y. Vodovotz, D. B. Stolz et al., “The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock,” Hepatology, vol. 42, no. 2, pp. 390–399, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Gordon, K. Gudi, A. Krause et al., “Circulating endothelial microparticles as a measure of early lung destruction in cigarette smokers,” American Journal of Respiratory and Critical Care Medicine, vol. 184, no. 2, pp. 224–232, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. V. Arpino, S. Mehta, L. Wang et al., “Tissue inhibitor of metalloproteinases 3-dependent microvascular endothelial cell barrier function is disrupted under septic conditions,” American Journal of Physiology-Heart and Circulatory Physiology, vol. 310, no. 11, pp. H1455–H1467, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Pan, A. Fei, L. Jing, X. Zhang, and C. Gao, “Increased circulating endothelial microparticles associated with PAK4 play a key role in ventilation-induced lung injury process,” BioMed Research International, vol. 2017, Article ID 4902084, 2017. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Gao, J. Tang, R. Li, and J. Huan, “Specific inhibition of AQP1 water channels in human pulmonary microvascular endothelial cells by small interfering RNAs,” Journal of Trauma and Acute Care Surgery, vol. 72, no. 1, pp. 150–161, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. J. P. Idrovo, “AICAR attenuates organ injury and inflammatory response after intestinal ischemia and reperfusion,” Molecular Medicine, vol. 20, pp. 676–683, 2015. View at Google Scholar
  22. C. Chen, P. Wang, Q. Su, S. Wang, and F. Wang, “Myosin light chain kinase mediates intestinal barrier disruption following burn injury,” PLoS ONE, vol. 7, no. 4, Article ID e34946, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Fan, F. Cheek, L. Chlan et al., “An official american thoracic society clinical practice guideline: the diagnosis of intensive care unit-acquired weakness in adults,” American Journal of Respiratory and Critical Care Medicine, vol. 190, no. 12, pp. 1437–1446, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. Z. Ruan, S. Liu, Y. Zhou et al., “Chlorogenic acid decreases intestinal permeability and increases expression of intestinal tight junction proteins in weaned rats challenged with LPS,” PLoS ONE, vol. 9, no. 6, Article ID e97815, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. J. C. Loftus, Z. Yang, J. Kloss, H. Dhruv, N. L. Tran, and D. L. Riggs, “A novel interaction between Pyk2 and MAP4K4 is integrated with glioma cell migration,” Journal of Signal Transduction, vol. 2013, Article ID 956580, pp. 1–12, 2013. View at Publisher · View at Google Scholar
  26. M. Aouadi, G. J. Tesz, S. M. Nicoloro et al., “Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation,” Nature, vol. 458, no. 7242, pp. 1180–1184, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. R. J. Roth Flach, A. Skoura, A. Matevossian et al., “Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis,” Nature Communications, vol. 6, article no. 8995, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Kadowaki, A. Morishita, T. Niki et al., “Galectin-9 prolongs the survival of septic mice by expanding tim-3-expressing natural killer T cells and PDCA-1+ CD11c+ macrophages,” Critical Care, vol. 17, no. 6, article no. R284, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Bosmann, J. J. Grailer, N. F. Russkamp et al., “CD11c+ alveolar macrophages are a source of IL-23 during lipopolysaccharide-induced acute lung injury,” Shock, vol. 39, no. 5, pp. 447–452, 2013. View at Publisher · View at Google Scholar · View at Scopus