The Prevalence and Replication Capacity of a Tibetan Dominant HBV Strain, C/D Recombinant

Figure 3

Recombination analysis of the selected Tibetan viral strain. Phylogenetic analysis data were also used as alignment data. The sequence similarity of the selected Tibetan strain to viral strains of all ten genotypes from A to J was analyzed. The position of nucleotide bases was shown in the abscissa and the similarity of the selected Tibetan strain to reference strains was shown in the ordinate. The numbering of HBV genome started from the restriction site of EcoR I downstream of preS2 initiation codon. Each curve represented one genotype and it showed the variation of sequence similarity between the selected Tibetan strain and the chosen reference sequence at each base site in the full genome. As shown, the dark blue curve, which was at the top left, implied that the fragment (nt1-1480) of the Tibetan HBV genome covering preS2/S region and X region had the highest similarity to genotype D. And the light grey curve, which was at the top right, implied that the rest of the genome had the highest similarity to genotype C.