Declining Physical Performance Associates with Serum FasL, miR-21, and miR-146a in Aging Sprinters
Table 2
Participant characteristics and blood parameters in different age groups and correlations of the variables with age.
A 18–39 yrs
B 50–66 yrs
C 66–79 yrs
D 79–90 yrs
Correlation with age (all groups)/
95% CI/coefficient of determination
Correlation with age (only B, C, D)/
95% CI/coefficient of determination
Anthropometrics and body composition
Height (cm)
180.1 ± 5.0
178.2 ± 8.1
172.8 ± 4.7
172.4 ± 4.9
−0.512 ()
−0.7 to −0.3 0.262
−0.464 ()
−0.7 to −0.2 0.215
Weight (kg)
78.3 ± 6.8
80.2 ± 9.7
71.0 ± 6.2
69.4 ± 6.4
−0.419 ()
−0.6 to −0.2 0.176
−0.568 ()
−0.7 to −0.3 0.323
LBM (kg)
67.2 ± 5.7
66.3 ± 7.0
60.2 ± 4.1
58.3 ± 4.8
−0.525 ()
−0.7 to −0.3 0.276
−0.564 ()
−0.7 to −0.3 0.318
Body fat mass (kg)
11.2 ± 4.1
13.9 ± 6.1
11.1 ± 3.7
11.2 ± 3.6
−0.028 ()
−0.3 to 0.2 0.001
−0.301 ()
−0.5 to 0.0 0.091
Blood cell count
WBC
5.6 ± 1.4
5.6 ± 1.0
5.7 ± 2.2 ()
5.4 ± 0.8 ()
−0.057 ()
−0.3 to 0.2 0.003
0.099 ()
−0.2 to 0.4 0.010
LYM%
39.2 ± 7.2
35.9 ± 6.2
34.2 ± 5.6 (
31.0 ± 9.4 ()
−0.384 ()
−0.6 to −0.2 0.147
−0.315 ()
−0.6 to 0.0 0.099
MXD%
12.3 ± 4.8
11.5 ± 3.0
11.5 ± 1.9 (
10.9 ± 2.4 ()
−0.174 ()
−0.4 to 0.1 0.030
−0.112 ()
−0.4 to 0.2 0.013
NEUT%
48.6 ± 8.5
52.6 ± 6.9
54.3 ± 6.6 (
58.1 ± 9.5 ()
0.411 ()
0.2 to 0.6 0.169
0.326 ()
0.0 to 0.6 0.106
RBC
5.1 ± 0.4
4.9 ± 0.4
4.9 ± 0.4 (
4.4 ± 0.3 ()
−0.443 ()
−0.6 to −0.2 0.187
−0.370 ()
−0.6 to −0.1 0.137
PLT
211.9 ± 44.0
242.3 ± 44.3
210.0 ± 83.6
199.7 ± 42.9 ()
−0.100 ()
−0.3 to 0.1 0.010
−0.375 ()
−0.6 to −0.1 0.141
HGB
154.3 ± 9.3
152.9 ± 12.4
149.4 ± 9.3
140.3 ± 8.0 ()
−0.383 ()
−0.6 to −0.2 0.147
−0.443 ()
−0.6 to −0.2 0.187
Serum molecules
hsCRP (mg/L)
1.6 ± 5.1
1.7 ± 3.3
2.3 ± 6.0 (
1.3 ± 1.2 ()
−0.035 () 0.784
−0.3 to 0.2 0.001
−0.102 ()
−0.4 to 0.2 0.010
FasL (pg/ml)
92.3 ± 24.7
56.8 ± 21.9 ()
56.0 ± 18.2
52.3 ± 23.4 ()
−0.596 ()
−0.7 to −0.4 0.355
−0.181 ()
−0.5 to 0.1 0.033
miR-21 (RE)
1.81 ± 0.75
2.22 ± 1.41
1.74 ± 1.05
1.65 ± 0.62
()
−0.3 to 0.1 0.009
()
−0.4 to 0.2 0.014
miR-146a (RE)
5.82 ± 2.66
1.83 ± 1.16
1.50 ± 0.71
1.51 ± 0.96
()
−0.7 to −0.4 0.373
()
−0.4 to 0.2 0.011
Table is formed based on the cross-sectional study design (2012) including all the athletes from ages 18 to 90 yrs. Results are presented as means ± SD. Age correlations are presented in two ways: (1) one including all the athletes and (2) one including only masters athletes. LBM: lean body mass, WBC: white blood cells, LYM: lymphocytes, MXD: mixed leukocytes, NEUT: neutrophils, RBC: red blood cells, PLT: platelet, HGB: hemoglobin, hsCRP: high sensitivity c-reactive protein, FasL: Fas-ligand, and RE: relative expression. Spearman’s correlation coefficient.
