Declining Physical Performance Associates with Serum FasL, miR-21, and miR-146a in Aging Sprinters
Table 3
The change in physical performance measures, self-reported training amounts, and serum molecule levels among all and age-grouped masters sprinters in the 10-year follow-up.
All 50–90 yrs
B 50–66 yrs
C 66–79 yrs
D 79–90 yrs
Training frequency
Change (times/wk)
−0.89 ± 1.22 ()
−0.91 ± 1.15 ()
−0.73 ± 1.43 ()
−1.06 ± 1.09 ()
value
P < 0.001
P = 0.011
P = 0.004
Sprint training
Change (h/wk)
−1.84 ± 3.00 ()
−1.80 ± 2.25 ()
−1.94 ± 4.08 ()
−1.77 ± 2.43 ()
values
P < 0.001
P = 0.009
P = 0.023
Other training
Change (h/wk)
−1.02 ± 2.62 ()
−1.53 ± 1.61 ()
−0.93 ± 3.44 ()
−0.56 ± 2.49 ()
value
P = 0.006
P = 0.008
P = 0.424
Sprint 60 m (s)
Change%
11.9 (6.7−16.5) ()
8.2 (5.7−10.0) ()
12.2 (5.7−16.4) ()
15.8 (12.1−22.8)
value
P <
P =
P =
P =
CMJ (cm)
Change%
−15.4 ± 10.2 ()
−9.2 ± 6.3 ()
−15.7 ± 10.0 ()
−22.0 ± 10.4 ()
value
P < 0.001
P = 0.001
P = 0.001
P < 0.001
Knee flexion (N)
Change%
−1.8 ± 23.6 ()
5.5 ± 29.0 ()
−3.6 ± 20.1 ()
−9.07 ± 18.0 ()
value
Isometric bench press (N)
Change%
−10.9 ± 11.9 ()
−5.3 ± 9.8 ()
−14.0 ± 14.7 ()
−14.9 ± 8.51 ()
value
P < 0.001
P = 0.036
P = 0.008
P < 0.001
hsCRP
Change%
112 ± 349 ()
203 ± 512 ()
71.5 ± 230 ()
56.8 ± 220 ()
value
FasL
Change%
−5.3 ± 26.3 ()
−18.3 ± 16.7 ()
1.22 ± 29.1 ()
1.78 ± 27.9 ()
value
P = 0.017
P = 0.001
miR-21
Change%
77.0 (1.1–689) ()
107 (21.0–662) ()
37.9 (−34.7–834) ()
136 (21.3–995) ()
value
P <
P =
P =
miR-146a
Change%
95.4 (−7.4–631) ()
93.0 (−3.0–1101) ()
18.6 (−26.0–444) ()
143 (53.6–861) ()
value
P =
P =
The age ranges of the groups (B, C, and D) represent the ages at follow-up. Data are presented as means ± SD for parametric variables and as median (IQR) for nonparametric variables. value was calculated with paired -test for normally distributed variables and with Wilcoxon signed rank test for nonparametric variables. Wilcoxon signed rank test for nonparametric variables. CMJ = countermovement jump, hsCRP = high sensitivity C-reactive protein, and FasL: Fas-ligand.
