Effect of Naringenin, Quercetin, and Sesamin on Xenobiotica-Metabolizing CYP1A and CYP3A in Mice Offspring after Maternal Exposure to Persistent Organic Pollutants

Table 1

Activities of CYP1A (EROD) and CYP3A (BROD) (pmol/min/mg pf protein) in the hepatic microsomes from mice of the unexposed, low-exposed, and high-exposed groups.

Enzyme	Level of exposure			value
	Unexposed	Low	High
CYP1A (EROD)				0.078
CYP3A (BROD)				0.018

EROD, 7-ethoxyresorufin O-dealkylase; BROD, 7-benzyloxyresorufin O-dealkylase. The activities were measured using a single substrate concentration (1 μM of 7-ethoxyresorufin for EROD, and 2 µM of 7-benzyloxyresorufin for BROD). EROD and BROD activities were expressed as pmol of resorufin per minute and milligram protein. Data are presented as geometric means and standard errors. value shows the overall effect of treatment on enzyme activity. Within a row mean values with different superscripts significantly differ ().