BioMed Research International

Research Article

Effect of Naringenin, Quercetin, and Sesamin on Xenobiotica-Metabolizing CYP1A and CYP3A in Mice Offspring after Maternal Exposure to Persistent Organic Pollutants

Table 2

IC₅₀ and values (µM) for naringenin, quercetin, and sesamin calculated for mice from the unexposed, low-exposed, and high-exposed groups.


Enzyme	Phytochemical	Level of exposure			value
Enzyme	Phytochemical	Unexposed	Low	High	value

CYP1A (EROD)	Quercetin
	IC₅₀	5.4 (1.5–19.6)	5.1 (1.7–15.8)	5.8 (3.2–10.5)	0.819
		1.7 (1.2–2.3)	2.6 (1.9–3.4)	2.6 (1.8–3.2)	0.721
	Naringenin		No inhibition
	Sesamin		No inhibition

CYP3A (BROD)	Quercetin
	IC₅₀	30.2 (10.4–41.7)	27.1 (9.3–28.7)	35.7 (20.4–83.2)	0.266
		67.1 (50.3–83.7)	64.9 (34.3–76.3)	75.3 (29.1–93.8)	0.893
	Naringenin
	IC₅₀	40.3 (9.5–112.3)	49.1 (11.5–98.4)	43.1 (20.2–98.5)	0.925
	Ki	42.1 (30.3–78.9)	45.8 (25.6–82.1)	39.3 (28.5–64.9)	0.271
	Sesamin		No inhibition

EROD, 7-ethoxyresorufin O-dealkylase; BROD, 7-benzyloxyresorufin O-dealkylase. Data are presented as geometric means and confidence interval in brackets. value shows the overall effect of group on IC₅₀ and values.