Advances in the Diagnosis and Treatment of Acute Kidney Injury in Cirrhosis Patients

Table 1

Current diagnostic criteria for acute kidney injury (AKI).

Criteria	Diagnostic criteria	Staging
RIFLE criteria	Increase in Scr to ≥1.5 times baseline within 7 days; GFR decrease >25%; or urine volume <0.5 ml/kg/h for 6 h	Risk. Scr increase of 1.5–1.9 times baseline; GFR decrease of 25–50%; or urine output < 0.5 ml/kg/h for 6 h; Injury. Scr increase of 2.0–2.9 times baseline; GFR decrease of 50–75%; or urine output < 0.5 ml/kg/h for 12 h; Failure. Scr increase ≥3.0 times baseline; GFR decrease of 50–75%; Scr increase ≥4.0 mg/dl (353.6 μmol/L) with an acute increase of at least 0.5 mg/dl (44 µmol/L); urine output < 0.3 ml/kg/h for ≥24 h; or anuria for ≥12 h
AKIN criteria	Increase in Scr by ≥0.3 mg/dl (26.5 µmol/L) within 48 h; increase in Scr ≥ 1.5 times baseline within 48 h; or urine volume < 0.5 ml/kg/h for 6 h	Stage 1. Scr increase of 1.5–1.9 times baseline; Scr increase ≥0.3 mg/dl (26.5 µmol/L); or urine output <0.5 ml/kg/h for 6 h; Stage 2. Scr increase of 2.0–2.9 times baseline or urine output <0.5 ml/kg/h for 12 h; Stage 3. Scr increase of 3.0 times baseline; Scr increase ≥4.0 mg/dl (353.6 µmol/L) with an acute increase of at least 0.5 mg/dl (44 µmol/L); urine output < 0.3 ml/kg/h for ≥24 h; or anuria for ≥12 h
KDIGO criteria	Increase in Scr by 0.3 mg/dl (26.5 µmol/L) within 48 h; increase in Scr to ≥1.5 times baseline that is known or presumed to have occurred within the previous 7 days; or urine volume < 0.5 ml/kg/h for 6 h	Stage 1. Scr increase of 1.5–1.9 times baseline; Scr increase ≥0.3 mg/dl (26.5 µmol/L); or urine output <0.5 ml/kg/h for 6–12 h; Stage 2. Scr increase of 2.0–2.9 times baseline or urine output < 0.5 ml/kg/h for ≥12 h; Stage 3. Scr increase of 3.0 times baseline; Scr increase to ≥4.0 mg/dl (353.6 µmol/L); initiation of renal replacement therapy; urine output < 0.3 ml/kg/h for ≥24 h; or anuria for ≥12 h