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BioMed Research International
Volume 2017, Article ID 8539747, 7 pages
Research Article

New Mydriasis-Free Electroretinogram Recorded with Skin Electrodes in Healthy Subjects

Department of Orthoptics and Visual Science, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan

Correspondence should be addressed to Ken Asakawa;

Received 12 February 2017; Revised 27 April 2017; Accepted 22 May 2017; Published 20 June 2017

Academic Editor: Gianluca Coppola

Copyright © 2017 Ken Asakawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To evaluate the reproducibility and consistency of the new mydriasis-free electroretinogram (ERG) with a skin electrode (RETeval) device, to determine the normative values of parameters, and to clarify the usefulness of pupil records to colored-light stimulus. Methods. A total of 100 eyes of 50 healthy subjects (mean age, 21.4 years) were enrolled. The diagnostic parameters obtained by the RETeval device were examined under the following conditions. The reproducibility was determined with the coefficient of variation (CV). The consistency was examined by intraclass correlation coefficients (ICCs). The mean value and the normal range were analyzed with a 95% confidence interval as the normative values of parameters. The correlation of parameters to pupil records (area ratio, constriction ratio) and flicker ERG was also examined in the diabetic retinopathy assessment protocol. Results. From the CV for each of the two measurements, the amplitude has a low reproducibility compared with the implicit time. Generally good consistency was obtained with both ERG parameters (ICCs = 0.48–0.92). Moderate correlations were found for the white-, red-, and blue-light stimulus in the area ratio and the constriction ratio, respectively ( = 0.44–0.62; = 0.010–<0.0001). No correlation was observed between pupil and flicker parameters ( = 0.06–0.34; = 0.646–0.051). Conclusions. The RETeval device was suggested as a possible screening device to detect the visual afferent diseases by evaluating in combination with the ERG recording and the colored-light pupil response.