In Vitro/In Silico Study on the Role of Doubling Time Heterogeneity among Primary Glioblastoma Cell Lines

Figure 1

Example of a cell (shown in black) attempting to proliferate. Firstly, the cell searches the 1-Moore neighborhood highlighted by the gray squares in (a). Being unable to find an empty space, it searches the 2-Moore neighborhood indicated by the gray squares in (b) and (c). As an empty space is found, the orange cell is pushed towards the empty space as shown in (b). The latter movement frees the empty space on the 1-Moore neighborhood and allows the proliferating cell to place an identical cell (also shown in black) to the adjacent empty space (c).

(a)

(b)

(c)