In Vitro/In Silico Study on the Role of Doubling Time Heterogeneity among Primary Glioblastoma Cell Lines

Figure 5

Monoclonal and polyclonal tumor area expansion. For the polyclonal case two scenarios are considered: one at which the number of phenotypes is 100 (green line) and another where 10 phenotypes are randomly selected (purple line). Each experiment is repeated 50 times and the corresponding standard deviation is also shown. The mean area of three monoclonal examples with doubling times 15.5 h (red dashed line), 25.5 h (blue dashed line), and 35.5 h (yellow dashed line) is also illustrated.