Research Article

Serum Proteome Alterations in Patients with Cognitive Impairment after Traumatic Brain Injury Revealed by iTRAQ-Based Quantitative Proteomics

Table 2

Differentially expressed proteins (DEPs) identified using iTRAQ coupled with LC-MS/MS.

NumberAccessionDescriptionMascot scoreCoverage (%)MW (kDa)Fold changeRegulation
Positive/negativePositive/HC

1A8MT79Putative zinc-alpha-2-glycoprotein-like 126.264.90230.767/Down
2O76076WNT1-inducible-signaling pathway protein 272.3111.6026.80.8180.768Down
3P01598Ig kappa chain V–I region EU119.2926.8511.8/0.827Down
4P01616Ig kappa chain V–II region MIL83.4733.0412/1.279Up
5P01620Ig kappa chain V–III region SIE318.5559.6311.8/0.824Down
6P01625Ig kappa chain V-IV region Len150.1736.8412.6/0.791Down
7P01701Ig lambda chain V–I region NEW4815.3211.41.39/Up
8P01717Ig lambda chain V-IV region Hil75.5317.7611.51.3191.297Up
9P01742Ig heavy chain V–I region EU58.2310.2612.51.2911.449Up
10P01764Ig heavy chain V–III region VH26109.9135.0412.6/0.773Down
11P01766Ig heavy chain V–III region BRO134.8325.0013.2/0.812Down
12P01768Ig heavy chain V–III region CAM106.723.7713.70.6740.595Down
13P01779Ig heavy chain V–III region TUR13826.7212.40.80.749Down
14P02655Apolipoprotein C-II344.5757.4311.3/1.353Up
15P02751Fibronectin4895.1452.68262.5/0.827Down
16P02788Lactotransferrin670.8834.5178.1/1.234Up
17P04180Phosphatidylcholine-sterol acyltransferase498.4729.7749.5/0.791Down
18P04278Sex hormone-binding globulin51.275.4743.81.2751.333Up
19P04406Glyceraldehyde-3-phosphate dehydrogenase170.0818.21360.4950.444Down
20P04434Ig kappa chain V–III region VH (fragment)65.3523.2812.70.680.781Down
21P05155Plasma protease C1 inhibitor167.0613.6055.1/1.208Up
22P06753Tropomyosin alpha-3 chain123.2510.8832.9/1.253Up
23P06858Lipoprotein lipase104.227.5853.10.808/Down
24P08185Corticosteroid-binding globulin22.271.9845.10.801/Down
25P08519Apolipoprotein(a)13025.625011.4361.62Up
26P0C0L5Complement C4-B5043.165.19192.61.226/Up
27P1102178 kDa glucose-regulated protein123.7210.5572.30.762/Down
28P11597Cholesteryl ester transfer protein210.4312.3754.71.229/Up
29P12814Alpha-actinin-1104.075.161031.321.373Up
30P15169Carboxypeptidase N catalytic chain69.717.2152.30.8270.808Down
31P23142Fibulin-11123.9842.1177.2/0.833Down
32P28066Proteasome subunit alpha type 548.134.9826.40.767/Down
33P29122Proprotein convertase subtilisin/kexin type 629.191.03106.4/0.777Down
34P35443Thrombospondin-4226.548.84105.81.2281.405Up
35P49913Cathelicidin antimicrobial peptide73.9312.3519.3/0.686Down
36P62158Calmodulin45.2726.1716.81.2551.224Up
37P68032Actin, alpha cardiac muscle 1244.1625.2042/1.214Up
38P68104Elongation factor 1-alpha 142.014.3350.10.77/Down
39P68366Tubulin alpha-4A chain66.676.2549.9/1.362Up
40P68871Hemoglobin subunit beta196.6752.3816/1.303Up
41Q02985Complement factor H-related protein 3160.2511.5237.3/1.212Up
42Q14515SPARC-like protein 1219.5917.7775.2/0.753Down
43Q6ZV73FYVE, RhoGEF, and PH domain-containing protein 636.671.12160.71.29/Up
44Q86UX7Fermitin family homolog 322.072.4075.90.80.798Down
45Q8IWZ6Bardet-Biedl syndrome 7 protein39.011.1280.3/1.24Up
46Q92540Protein SMG734.490.70127.2/1.222Up
47Q92954Proteoglycan 4233.657.05151/0.829Down
48Q96KK5Histone H2A type 1-H82.2921.8813.9/0.735Down
49Q9H4B7Tubulin beta-1 chain57.956.2150.30.740.81Down
50Q9H6R4Nucleolar protein 633.170.61127.50.793/Down
51Q9NUD7Uncharacterized protein C20orf9627.392.4842.8/1.229Up
52Q9UBU7Protein DBF4 homolog A42.740.8976.8/1.367Up
53Q9UHG3Prenylcysteine oxidase 1248.9715.8456.6/0.819Down
54Q9UK55Protein Z-dependent protease inhibitor615.9331.9850.70.8250.717Down
55Q9Y490Talin-1611.61269.61.2481.427Up
56Q9Y5C1Angiopoietin-related protein 340.671.7453.6/1.268Up

Note: regulation: up or down indicates the DEPs that were upregulated or downregulated, respectively, in the positive group relative to the reference groups.