Screening for Key Pathways Associated with the Development of Osteoporosis by Bioinformatics Analysis

Table 3

Pathways enriched by subnetwork modules.

Module	Gene set	Protein from module	FDR
0	Transcriptional regulation of white adipocyte differentiation (R)	6
0	Chromatin modifying enzymes (R)	6
1	Mitotic metaphase and anaphase (R)	23
1	Signaling by Rho GTPases (R)	21
3	Synthesis of DNA (R)	11
3	S phase (R)	11
4	DNA damage bypass (R)	8
4	Fanconi anemia pathway (N)	9
5	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway (P)	5
5	Wnt signaling pathway (P)	6
6	Protein kinase a at the centrosome (B)	2
6	Prostate cancer (K)	3
7	Signaling by Rho GTPases (R)	8
7	Regulation of RhoA activity (N)	2
8	Mitotic telophase/cytokinesis (R)	4
8	Mitotic prometaphase (R)	4
9	Interferon alpha/beta signaling (R)	5
9	ISG15 antiviral mechanism (R)	4
10	Cadherin signaling pathway (P)	6
10	Wnt signaling pathway (P)	6
11	Nucleosome assembly (R)	9
11	Mitotic prometaphase (R)	6
12	Beta1 integrin cell surface interactions (N)	4
12	ECM-receptor interaction (K)	3
13	Formation of fibrin clot (clotting cascade) (R)	2
13	AP-1 transcription factor network (N)	2
14	TGF-beta signaling pathway (P)	4
14	TGF-beta signaling pathway (K)	4
15	Insulin-mediated glucose transport (N)	2
15	Class I PI3K signaling events mediated by Akt (N)	2

The source of pathway database: C: CellMap, R: Reactome, K: KEGG, N: NCI PID, P: Panther, and B: BioCarta.