Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1β-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-κB Pathway

Figure 1

Influence of SAMC on chondrocytes viability. (a) Chondrocytes were treated SAMC with 0, 5, 10, 20, 40, 60, 80, and 100 μM, and then cell viability was measured by MTT assay. (b) Chondrocytes were treated with IL-1β, SAMC alone (60 μM), IL-1β plus SAMC (20 and 60 μM), or IL-1β plus dexamethasone for 48 h, and then cell viability was measured. (c) DAPI staining of chondrocytes showed apoptotic body (arrow) after 48 h treatment. Data represent the mean ± SD of experiments in triplicate (Bars SD). , versus IL-1β group; , versus dexamethasone group.

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