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BioMed Research International
Volume 2017 (2017), Article ID 8701386, 9 pages
Research Article

Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma

1Department of Morphofunctional Sciences I-Histology, Pathology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
2Department of Pathology, Institute of Legal Medicine, Iasi, Romania
3Department of Pathology, “Sf. Spiridon” County Clinical Emergency Hospital, Iasi, Romania

Correspondence should be addressed to Cornelia Amalinei

Received 7 April 2017; Revised 19 November 2017; Accepted 3 December 2017; Published 25 December 2017

Academic Editor: Fotios Loupakis

Copyright © 2017 Simona Eliza Giusca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Periostin (PN) epithelial and stromal overexpression in tumor pathology has been studied according to tumor growth, angiogenesis, invasiveness, and metastasis, but a limited number of studies address PN in thyroid tumors. Aim. Our study aimed to analyze PN expression in different histological variants of PTC and to correlate its expression with the clinicopathological prognostic factors. Material and Methods. PN expression has been immunohistochemically assessed in 50 cases of PTC (conventional, follicular, oncocytic, macrofollicular, and tall cell variants), in tumor epithelial cells and intratumoral stroma. The association between PN expression and clinicopathological characteristics has been evaluated. Results. Our results show that PTC presented different patterns of PN immunoreaction, stromal PN being significantly associated with advanced tumor stage and extrathyroidal extension. No correlations were found between PN overexpression in tumor epithelial cells and clinicopathological features, except for specific histological variants, the highest risk of poor outcome being registered for the conventional subtype in comparison to the oncocytic type. Conclusions. Our study demonstrates differences in PN expression in histological subtypes of PTC. Our results plead in favor of a dominant protumorigenic role of stromal PN, while the action of epithelial PN is less noticeable.