Combined Transcriptomic Analysis Revealed AKR1B10 Played an Important Role in Psoriasis through the Dysregulated Lipid Pathway and Overproliferation of Keratinocyte

Table 3

Pathway enrichment analysis of 696 common DEGs.

Term	Count	%	value	Genes
hsa03320: PPAR signaling pathway	12	1.7		ACOX2, LPL, PPARD, ACSL1, HMGCS2, PPARG, FADS2, FABP7, ACADL, SLC27A2, MMP1, FABP5
hsa04060: cytokine-cytokine receptor interaction	25	3.6		CXCL1, TNFRSF21, IL19, IL21R, CXCL9, CXCR2, CXCR3, KIT, IL7R, CCL20, CXCR4, IL4R, IL1B, IL6, IL18RAP, IL2RA, IL8, LIFR, EDAR, CCL18, IL20, CCR7, CCR5, CXCL13, EDA
hsa00592: alpha-linolenic acid metabolism	6	0.8		JMJD7-PLA2G4B, PLA2G2A, FADS2, PLA2G3, PLA2G4B, PLA2G4E, PLA2G2F
hsa00601: glycosphingolipid biosynthesis	6	0.8		FUT9, B3GALT5, FUT3, B3GNT3, FUT1, FUT2
hsa00591: linoleic acid metabolism	6	0.8		JMJD7-PLA2G4B, AKR1B15, AKR1B10, PLA2G2A, PLA2G3, PLA2G4B, PLA2G4E, PLA2G2F
hsa04640: hematopoietic cell lineage	10	1.4		IL6, IL2RA, CD3G, CD3D, CD3E, IL4R, CD2, IL1B, KIT, IL7R
hsa04062: chemokine signaling pathway	16	2.3		CXCL1, ITK, LYN, IL8, CXCL9, CXCR2, CXCR3, STAT1, CCL18, CCR7, PLCB4, CCR5, CCL20, CXCR4, CXCL13, JAK3
hsa00565: ether lipid metabolism	6	0.8		JMJD7-PLA2G4B, PLA2G2A, PLA2G3, PLA2G4B, CHPT1, PLA2G4E, PLA2G2F
hsa05340: primary immunodeficiency	6	0.8		CD3D, CD3E, ICOS, LCK, JAK3, IL7R
hsa00603: glycosphingolipid biosynthesis	4	0.5		FUT9, B3GALT5, FUT1, FUT2
hsa00564: glycerophospholipid metabolism	8	1.1		GPD1, JMJD7-PLA2G4B, PLA2G2A, PLA2G3, PNPLA3, PLA2G4B, CHPT1, PLA2G4E, PLA2G2F
hsa04730: long-term depression	8	1.1		JMJD7-PLA2G4B, PLCB4, GRIA2, LYN, PLA2G2A, PLA2G3, PLA2G4B, PLA2G4E, PLA2G2F
hsa00590: arachidonic acid metabolism	7	1.0		JMJD7-PLA2G4B, ALOX15B, PLA2G2A, ALOX12B, PLA2G3, PLA2G4B, PLA2G4E, PLA2G2F
hsa04514: cell adhesion molecules (CAMs)	11	1.6		CLDN16, CLDN8, CD80, NRXN3, SELL, ICOS, CD274, CD2, CTLA4, CDH2, CD226