Combined Transcriptomic Analysis Revealed AKR1B10 Played an Important Role in Psoriasis through the Dysregulated Lipid Pathway and Overproliferation of Keratinocyte

Table 4

GO annotation results of 696 common DEGs.

Term	Count	%	value	Genes
GO:0031424~keratinization	15	4.7		HRNR, LCE3A, LCE3D, SPRR2G, SPRR2F, LCE1B, SPRR2E, SPRR2C, SPRR2D, SPRR1B, SPRR2A, SPRR2B, CNFN, TGM1, TGM3, LCE3E
GO:0007398~ectoderm development	25	7.9		HRNR, KRT6A, KRT6B, LCE3A, S100A7, CRABP2, LCE3D, SPRR2G, LCE1B, SPRR2F, SPRR2E, SPRR2C, SPRR2D, SPRR2A, SPRR2B, TGM1, ALOX12B, TGM3, GRHL3, EDAR, KRT16, SPRR1B, CNFN, LCE3E, EDA, FABP5
GO:0030216~keratinocyte differentiation	16	5.0		HRNR, LCE3A, S100A7, LCE3D, SPRR2G, SPRR2F, LCE1B, SPRR2E, SPRR2C, SPRR2D, SPRR1B, SPRR2A, SPRR2B, CNFN, TGM1, TGM3, LCE3E
GO:0009913~epidermal cell differentiation	16	5.0		HRNR, LCE3A, S100A7, LCE3D, SPRR2G, SPRR2F, LCE1B, SPRR2E, SPRR2C, SPRR2D, SPRR1B, SPRR2A, SPRR2B, CNFN, TGM1, TGM3, LCE3E
GO:0006955~immune response	44	14.0		CXCL1, KYNU, S100A7, IL19, OAS3, RSAD2, OAS1, OAS2, DEFB4A, IL7R, PNP, NOD2, CCL20, RAET1G, HRH2, IL4R, BCL3, VNN1, IL1B, LTF, CCBP2, NOS2, FCGR3A, GBP6, IL18RAP, GBP5, LYN, IL8, CTLA4, CD300E, SLAMF7, AIM2, OASL, CCR7, APOL1, CST7, CXCL13, CD274, SERPINB4, CLEC7A, EDA, IFI6, PTAFR, GBP1
GO:0008544~epidermis development	23	7.3		HRNR, LCE3A, S100A7, LCE3D, CRABP2, SPRR2G, GRHL3, SPRR2F, LCE1B, SPRR2E, EDAR, SPRR2C, SPRR2D, KRT16, SPRR1B, SPRR2A, TGM1, SPRR2B, CNFN, ALOX12B, TGM3, LCE3E, EDA, FABP5
GO:0030855~epithelial cell differentiation	18	5.7		HRNR, LCE3A, S100A7, LCE3D, SPRR2G, SPRR2F, LCE1B, SPRR2E, RHCG, SPRR2C, SPRR2D, SPRR1B, SPRR2A, UPK1B, SPRR2B, CNFN, TGM1, TGM3, LCE3E
GO:0060429~epithelium development	19	6.0		HRNR, LCE3A, S100A7, LCE3D, SPRR2G, SPRR2F, LCE1B, SPRR2E, RHCG, SPRR2C, SPRR2D, FREM2, SPRR1B, SPRR2A, UPK1B, SPRR2B, CNFN, TGM1, TGM3, LCE3E
GO:0006952~defense response	31	9.8		CXCL1, KYNU, S100A8, S100A7, S100A9, RSAD2, CXCR2, DEFB4A, NOD2, CCL20, VNN1, IL1B, LTF, BCL3, SERPINA1, NOS2, MX1, IRAK2, IL18RAP, LYN, IL8, LYZ, SLAMF7, IDO1, S100A12, CCR7, APOL1, CXCL13, IRF7, CLEC7A, PTAFR
GO:0002684~positive regulation of immune system process	17	5.4		IRAK2, LYN, CD247, PTPN22, IDO1, IL7R, PNP, PRKCQ, NOD2, CD80, IL4R, CD2, IL1B, VNN1, CLEC7A, NOS2, CD226