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BioMed Research International
Volume 2017, Article ID 8727434, 7 pages
https://doi.org/10.1155/2017/8727434
Research Article

Identification and Characterization of a Splicing Variant in the 5′ UTR of the Human TLR5 Gene

Department of Life Science, Gachon University, Seongnam, Gyeonggi-do 461-701, Republic of Korea

Correspondence should be addressed to Jae Young Kim; rk.ca.nohcag@58mikyj

Received 6 May 2017; Revised 2 August 2017; Accepted 2 August 2017; Published 29 August 2017

Academic Editor: Torsten Goldmann

Copyright © 2017 Thi Xoan Hoang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Kawai and S. Akira, “TLR signaling,” Seminars in Immunology, vol. 19, no. 1, pp. 24–32, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. V. Haehnel, L. Schwarzfischer, M. J. Fenton, and M. Rehli, “Transcriptional regulation of the human Toll-like receptor 2 gene in monocytes and macrophages,” Journal of Immunology, vol. 168, no. 11, pp. 5629–5637, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. E. LeBouder, J. E. Rey-Nores, N. K. Rushmere et al., “Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk,” Journal of Immunology, vol. 171, no. 12, pp. 6680–6689, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Jordan, S. Schornack, and T. Lahaye, “Alternative splicing of transcripts encoding toll-like plant resistance proteins - What's the functional relevance to innate immunity?” Trends in Plant Science, vol. 7, no. 9, pp. 392–398, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. C. A. Wells, A. M. Chalk, A. Forrest et al., “Alternate transcription of the Toll-like receptor signaling cascade,” Genome Biology, vol. 7, no. 2, article no. R10, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. F. L. Rock, G. Hardiman, J. C. Timans, R. A. Kastelein, and J. F. Bazan, “A family of human receptors structurally related to Drosophila Toll,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 2, pp. 588–593, 1998. View at Publisher · View at Google Scholar · View at Scopus
  7. X. Du, A. Poltorak, Y. Wei, and B. Bruce, “Three novel mammalian toll-like receptors: gene structure, expression, and evolution,” Eur. Cytokine Netw, vol. 11, no. 3, pp. 362–371, 2000. View at Google Scholar
  8. K. Burns, S. Janssens, B. Brissoni, N. Olivos, R. Beyaert, and J. Tschopp, “Inhibition of interleukin 1 receptor/toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4,” Journal of Experimental Medicine, vol. 197, no. 2, pp. 263–268, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Janssens, K. Burns, E. Vercammen, J. Tschopp, and R. Beyaert, “MyD88S, a splice variant of MyD88, differentially modulates NF-κB- and AP-1-dependent gene expression,” FEBS Letters, vol. 548, no. 1-3, pp. 103–107, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. M. P. Hardy and L. A. J. O'Neill, “The murine Irak2 gene encodes four alternatively spliced isoforms, two of which are inhibitory,” Journal of Biological Chemistry, vol. 279, no. 26, pp. 27699–27708, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Rao, S. Nguyen, K. Ngo, and W.-P. Fung-Leung, “A novel splice variant of interleukin-1 receptor (IL-1R)-Associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling,” Molecular and Cellular Biology, vol. 25, no. 15, pp. 6521–6532, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Vidal-Petiot, L. Cheval, J. Faugeroux et al., “A new methodology for quantification of alternatively spliced exons reveals a highly tissue-specific expression pattern of WNK1 isoforms,” PLoS ONE, vol. 7, no. 5, Article ID e37751, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. H.-M. Zeng, K.-F. Pan, Y. Zhang et al., “Genetic variants of toll-like receptor 2 and 5, Helicobacter Pylori infection, and risk of gastric cancer and its precursors in a Chinese population,” Cancer Epidemiology Biomarkers and Prevention, vol. 20, no. 12, pp. 2594–2602, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. D. S. O'Mahony, U. Pham, R. Iyer, T. R. Hawn, and W. C. Liles, “Differential constitutive and cytokine-modulated expression of human Toll-like receptors in primary neutrophils, monocytes, and macrophages,” International Journal of Medical Sciences, vol. 5, no. 1, pp. 1–8, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. C. A. Leifer, C. McConkey, S. Li, B. Chassaing, A. T. Gewirtz, and R. E. Ley, “Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation,” Immunology Letters, vol. 162, no. 2, pp. 3–9, 2014. View at Publisher · View at Google Scholar
  16. B. Modrek, A. Resch, C. Grasso, and C. Lee, “Genome-wide detection of alternative splicing in expressed sequences of human genes,” Nucleic Acids Research, vol. 29, no. 13, pp. 2850–2859, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Rosentiel, K. Huse, A. Franke et al., “Functional characterization of two novel 5′ untranslated exons reveals a complex regulation of NOD2 protein expression,” BMC Genomics, vol. 8, article no. 472, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Wang, X. Guo, and J. Floros, “Differences in the translation efficiency and mRNA stability mediated by 5′-UTR splice variants of human SP-A1 and SP-A2 genes,” American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 289, no. 3, pp. L497–L508, 2005. View at Publisher · View at Google Scholar · View at Scopus