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BioMed Research International
Volume 2017 (2017), Article ID 8968604, 8 pages
https://doi.org/10.1155/2017/8968604
Research Article

In Vitro Biological Screening of Hartmannia rosea Extracts

1Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
2Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan
3School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
4Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan

Correspondence should be addressed to Rehana Rashid and Yi Lu

Received 14 June 2017; Revised 23 August 2017; Accepted 6 September 2017; Published 4 December 2017

Academic Editor: Wan-Liang Lu

Copyright © 2017 Rehana Rashid et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study is focused on the assessment of the medicinal therapeutic potential extracts of H. rosea to investigate their pharmacological implications based upon science proofs. The antioxidant activity of fraction of H. rosea, namely, -hexane (HR-1), ethyl acetate (HR-2), chloroform (HR-3), and -butanol (HR-4), was performed by using the DPPH radical scavenging method. The cytotoxicity and enzyme inhibition assessment were also performed. All the extracts showed significant antioxidant, antibacterial, and protein kinase inhibition but none of the extracts exhibited α-amylase inhibition activity. The chloroform extract HR-3 may block a kinase receptor from binding to ATP; the lead molecule will be isolated, which may stop cancerous cell growth and demotion of cell division. It is predicted that ethyl acetate, chloroform, and -butanol extracts of H. rosea contain polyphenolics, flavonoids, and alkaloids that are biologically effective candidates exhibiting significant cytotoxicity, antioxidant, and antimicrobial activities. They may control oxidative damage in the body tissues and act as potential antidiabetic and anticancer agents. These studies will also be helpful for future drug designing and drug development research.