BioMed Research International / 2017 / Article / Tab 1 / Review Article
Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis Table 1 Basic characteristics and quality assessment of included studies.
Study Design Age (years) Region (subgroup) HPV type HPV infection time Indexes Follow-up time (months) Quality rating Sagasta et al. (2016) [10 ] Prospective Spain (Europe) HR-HPV NR ①②③ 28 8 Veijalainen et al. (2015) [11 ] Retrospective 40.4 Finland (Europe) HR-HPV NR ① 96 8 He et al. (2015) [12 ] Retrospective China (Asia) HR-HPV NR ①②③ 15 (8–24) 9 Zhou et al. (2015) [13 ] Prospective China (Asia) HR-HPV NR ③ 24 7 Mou et al. (2014) [14 ] Retrospective China (Asia) NR NR ①②③ 36 7 Siriaunkgul et al. (2014) [15 ] Prospective 46.6 Thailand (Asia) NR NR ①②③ 24 8 Hu et al. (2014) [16 ] Prospective 30–59 China (Asia) HR-HPV Transient ①②③ 24 9 Persistent ①②③ Jiang (2013) [17 ] Retrospective China (Asia) HR-HPV NR ①②③ 24 8 Waldstrøm et al. (2013) [18 ] Prospective 32.3 Denmark (Europe) NR NR ①②③ 60 8 Katki et al. (2013) [19 ] Prospective 30–64 United States (America) NR NR ①②③ 60 8 Byun et al. (2013) [20 ] Prospective 46 Korea (Asia) HR-HPV NR ① 8 8 Liao et al. (2013) [21 ] Prospective 30–49 China (Asia) HR-HPV NR ① 36 8 Li et al. (2013) [22 ] Prospective 38 China (Asia) HR-HPV NR ③ 6 8 Wang et al. (2012) [6 ] Retrospective 35.4 (20–53) China (Asia) HR-HPV Persistent ① 18.6 (8–24) 9 Huang et al. (2012) [23 ] Retrospective 30 (22–70) China (Asia) HR-HPV NR ① 24 7 Bowring et al. (2012) [24 ] Prospective Britain (Europe) HR-HPV NR ①②③ 12 8 Jakobsson et al. (2012) [25 ] Retrospective 34 Finland (Europe) HR-HPV NR ① 6 8 Ozaki et al. (2011) [26 ] Prospective 39 Japan (Asia) NR NR ① 17 7 Li and Yang (2011) [5 ] Prospective China (Asia) HR-HPV NR ①②③ 6 8 LR-HPV ②③ Gonzalez-Bosquet et al. (2010) [27 ] Prospective 32.25 Germany (Europe) HR-HPV NR ① 25 7 Waldstrøm and Ømskov (2010) [28 ] Retrospective 32 Denmark (Europe) NR NR ①②③ 36 8 Heider et al. (2010) [29 ] Retrospective 33 United States (America) HR-HPV NR ①②③ 34 9 Cotton et al. (2010) [30 ] Prospective 20–59 Britain (Europe) HR-HPV NR ① 36 8 Thrall et al. (2009) [7 ] Prospective ≥30 United States (America) HR-HPV NR ①②③ 24 9 Liao (2008) [31 ] Prospective 30–49 China (Asia) HR-HPV NR ③ 24 7 Gong (2007) [1 ] Prospective China (Asia) HR-HPV Transient ①②③ 24 7 Persistent ①②③ Luis Ferreira Santos et al. (2006) [32 ] Prospective 31 (16–63) United States (America) NR NR ①②③ 12 8 Tarkkanen et al. (2006) [33 ] Prospective 35 (20–60) Finland (Europe) NR NR ① 6 7 Song et al. (2006) [34 ] Retrospective 38 Korea (Asia) NR NR ①②③ 24 8 Clavel et al. (2005) [35 ] Retrospective 30 France (Europe) HR-HPV NR ①②③ 24 8 Massad et al. (2004) [36 ] Prospective 37.4 United States (America) HR-HPV NR ①②③ 90 8 LR-HPV NR ①②③ Sastre-Garau et al. (2004) [37 ] Retrospective 31 France (Europe) HR-HPV NR ①③ 24 8 Alameda et al. (2004) [38 ] Retrospective 25–45 Spain (Europe) HPV NR ②③ 24 7 Schlecht et al. (2003) [39 ] Retrospective 16–65 Brazil (America) HR-HPV NR ① 53.3 8 LR-HPV NR ① Denise Zielinski et al. (2001) [40 ] Retrospective 40.5 (20–76) Holland (Europe) HR-HPV NR ①②③ 16.8 (0–54) 8 Matsuura et al. (1997) [41 ] Prospective NR United States (America) NR NR ①②③ 8 Kaufman et al. (1997) [42 ] Retrospective NR United States (America) HR-HPV NR ①③ 6 7 Campion et al. (1986) [43 ] Prospective <30 Britain (Europe) NR NR ①②③ 22.4 (19–30) 7
Note . ①: the relative risk (RR) of progression of CIN1 patients of HPV-positive compared with the HPV-negative; ②: the relative risk (RR) of persistence of CIN1 patients of HPV-positive compared with the HPV-negative; ③: the relative risk (RR) of regression of CIN1 patients of HPV-positive compared with the HPV-negative. HPV, human papillomavirus; HR-HPV, high-risk HPV; LR-HPV, low-risk HPV; HPV(+), HPV-positive; NR, not reported.