Review Article

The Strategy to Prevent and Regress the Vascular Calcification in Dialysis Patients

Table 1

Types of vascular calcification.

TypeCharacteristics/risk factorsComplication

Atherosclerotic intimal calcificationCalcification of atherosclerotic plaques; eccentric lumen deformation by patchy calcification of the intima in the vicinity of lipid or cholesterol deposits as present in plaque calcification; patch or striped calcification on X-ray examination. Risk factors include hypercholesterolemia, metabolic syndrome, diabetes, and hypertension.Ischemia/infarction
Arterial medial calcificationCalcification of the media in the absence of such lipid or cholesterol deposits, known as Mönckeberg-type atherosclerosis; tram-like or pipe calcification by X-ray examination. Risk factors include abnormal calcium-phosphate metabolism and inflammation.Systolic hypertension, left ventricular hypertrophy
Heart valve calcificationCalcification of aortic valve or mitral valve leaflets as a consequence of abnormal calcium-phosphate metabolism, inflammation, and traditional cardiovascular risk factors such as hypercholesterolemia, metabolic syndrome, diabetes, and hypertension.Heart failure
Calcific uremic arteriolopathyDermal arteriolar medial calcification and dermal fat necrosis, usually in the abdomen, thighs, breasts, and buttocks. X-ray examination of the extremities including the hands and feet reveals calcified artery in the absence of thrombosis. Risk factors include diabetes, obesity, vitamin K antagonist, and steroid.Painful nodule and subcutaneous skin/fat necrosis wound