Phagocytosis: A Fundamental Process in Immunity

Table 1

Human phagocytic receptors and their ligands.

Receptor	Ligands	Reference(s)
Pattern-recognition receptors
Dectin-1	Polysaccharides of some yeast cells	[29]
Mannose receptor	Mannan	[30]
CD14	Lipopolysaccharide-binding protein	[31]
Scavenger receptor A	Lipopolysaccharide, lipoteichoic acid	[32, 33]
CD36	Plasmodium falciparum-infected erythrocytes	[40]
MARCO	Bacteria	[41]
Opsonic receptors
FcγRI (CD64)	IgG1 = IgG3 > IgG4	[42]
FcγRIIa (CD32a)	IgG3 ≥ IgG1 = IgG2	[42]
FcγRIIIa (CD16a)	IgG	[42]
FcαRI (CD89)	IgA1, IgA2	[11, 43]
FcεRI	IgE	[44]
CR1 (CD35)	Mannan-binding lectin, C1q, C4b, C3b	[45]
CR3 (β2, CD11b/CD18, Mac-1)	iC3b	[46]
CR4 (β2, CD11c/CD18, gp190/95)	iC3b	[46]
α5β1	Fibronectin, vitronectin	[47]
Apoptotic body receptors
TIM-1	Phosphatidylserine	[48]
TIM-4	Phosphatidylserine	[48]
Stabilin-2	Phosphatidylserine	[49]
BAI-1	Phosphatidylserine	[50]
β3	MFG-E8	[51]
β5	Apoptotic cells	[52]
CD36	Oxidized lipids	[53]

TIM, T cell immunoglobulin mucin; BAI-1, brain-specific angiogenesis inhibitor 1; MFG, milk fat globule.