Research Article

The Phytoestrogen Genistein Produces Similar Effects as 17β-Estradiol on Anxiety-Like Behavior in Rats at 12 Weeks after Ovariectomy

Table 1

Effects of 17β-estradiol, and genistein on crossing, grooming, and rearing in the locomotor activity test.

GroupsCrossing (n)Grooming (s) Rearing (s)

Vehicle39.7 ± 3.7 ± ±
17β-Estradiol (mg/kg)
 0.045 ± ± ±
 0.09 ±
 0.18 ±
Genistein (mg/kg)
 0.045 ± ± ±
 0.09 ±
 0.18 ±

, versus vehicle and 0.045 mg/kg 17β-estradiol and genistein; , versus the same doses of 17β-estradiol. One-way ANOVA followed by Student-Newman-Keuls post hoc test.