Review Article

A Review on Recent Computational Methods for Predicting Noncoding RNAs

Table 4

Sequencing-assembling based whole ncRNA set methods.

NameURLFeaturePrediction algorithm

Tilling array [47]http://www.genomebiology.com/2014/15/3/R48Synonymous amino acid substitutions, reading frame conservation, and the occurrence of premature stop codonsRNAcode algorithm and biweight kernels

DigitagCT [48]http://cractools.gforge.inria.fr/softwares/digitagctGenomic sequences, DGE tags, and tiling array expressionInfernal and BLASTN

BlockClust [49]http://toolshed.g2.bx.psu.edu/view/rnateam/blockclust_workflow(1) The block group: entropy of read starts, entropy of read ends, entropy of read lengths, median of normalized read expressions and normalized read expression levels in first quantile; (2) block: number of multimapped reads, entropy of read lengths, entropy of read expressions, minimum read length and block length, and (3) block edge: contiguity and difference in median read expressionsGraph-kernel SVM

Noncoder [50]http://noncoder.mpi-bn.mpg.de/Sequence homology, evolutionary information, the longest reading frame in three forward frames, log-odds score, coverage of the predicted orf, and integrity of the predicted orfBLAT and PhyloCSF

Vicinal [51]http://nar.oxfordjournals.org/content/42/9/e79.full.pdf+htmlChimeric RNA-cDNA fragments and terminal stem-loopBowtie 2 local mapping, filtering, and Vicinal mapping

CoRAL [52]http://nar.oxfordjournals.org/content/41/14/e137.full.pdf+htmlRead length, abundance of antisense transcription, 5′ and 3′ positional entropy, four nucleotide frequencies transformed into a log-odds ratio relative to equal base frequencies, and MFEMulticlass classification random forest

FlaiMapper [53]http://www.ncbi.nlm.nih.gov/pubmed/25338717Densities of start and end positions of aligned reads and read lengthsPeak detection on the start and end position densities followed by filtering and a reconstruction process