BioMed Research International / 2017 / Article / Tab 6 / Review Article
A Review on Recent Computational Methods for Predicting Noncoding RNAs Table 6 Methods to predict lncRNAs.
Name Feature Prediction algorithm Estimating lincRNome size for human [63 ] lincRNA numbers validated experimentally in human and mouse, and their overlap lincRNA number System of nonlinear equations Classifying human lncRNA [64 ] RNA sequence-structure patterns (RSSPs) describing 42 highly structured families, motif binding sites extracted as 1314 Position-Weight Matrices (PWMs), all -words of length , the sequence complexity Classifying human lncRNA by being able (or disable) to bind the polycomb repressive complex (PRC2), SVM with linear kernel Identify, classify, and localize maize lncRNAs [65 ] Transcript length, open reading frame (ORF) size, and homology with known proteins SVM The GENCODE v7 catalog of human lncRNA [66 ] Lack of homology with known proteins, no reasonable-sized open reading frame (ORF), and no high conservation, confirmed by PhyloCSF through the majority of exons conserved promoters Manual annotation and pattern recognition Highly conserved large noncoding RNAs [67 ] Chromatin signatures “K4–K36” domain Maximum CSF score observed across the entire genomic locus