Preimplantation Genetic Diagnosis for Myotonic Dystrophy Type 1 and Analysis of the Effect of the Disease on the Reproductive Outcome of the Affected Female Patients
Table 1
Clinical data for PGD of DM1 at HUVR.
Couples with affected female
Couples with affected male
Total
Couples with haemophilia A
Number of couples treated
22
13
35
18
Maternal age
33.2 ± 3.7
32.1 ± 3.8
32.7 ± 3.7
31.8 ± 2.9
Number of cycles performed
33
26
59
29
Number of cycles performed per couple
1.5 ± 0.7
2.0 ± 0.6
1.7 ± 0.7
1.7 ± 0.8
Number of oocytes retrieved
458
380
838
570
Number of oocytes retrieved per cycle
13.9 ± 7.9
14.6 ± 8.5
14.2 ± 8.1
18.4 ± 10.1
Number of mature oocytes submitted to ICSI
288
272
560
408
% of mature oocytes out of total oocytes retrieved
62.9
71.6
66.8
71.6
Number of mature oocytes submitted to ICSI per cycle
8.7 ± 5.8
10.5 ± 5.7
9.5 ± 5.8
13.6 ± 7.3
Number of oocytes fertilized
141
157
298
264
% of oocytes fertilized
48.9
57.7
53.2
64.7
Number of oocytes fertilized per cycle
4.3 ± 3.9
6.3 ± 4.2
5.1 ± 4.1
8.8 ± 5.6
Number of embryos analyzed
108
114
222
205
% of embryos analyzed
76.6%
72.6%
74.5%
77.7%
Number of embryos analyzed per cycle
3.3 ± 3.1
5.1 ± 2.6
3.8 ± 3.1
6.8 ± 4.5
Number of informative embryos
96
104
200
180
% of informative embryos
88.9%
91.2%
89.6%
87.8%
Number of transfers
20
18
38
26
% of transfers
60.6%
69.2%
64.4%
89.7%
Number of embryos transferred
29
29
58
48
Number of embryos transferred per cycle
0.9 ± 0.8
1.1 ± 0.9
1.0 ± 0.8
1.5 ± 0.8
Number of biochemical pregnancies
7
10
17
12
Number of clinical pregnancies
5
6
11
7
% of clinical pregnancies per cycle
15.5%
23.1%
18.6%
24.1%
% of clinical pregnancies per transfer
25.0%
33.3%
28.9%
26.9%
Implantation rate
17.2%
20.7%
19.0%
16.7%
Number of pregnancies went to term
5
5
10
7
Number of babies born
5
6
11
8
Live birth rate per cycle
15.2%
23.1%
18.6%
24.1%
Bold-typed are the parameters that are significantly different when comparing the group of couples with an affected female versus the one with an affected male or versus the group of couples of PGD for haemophilia A.
