Preimplantation Genetic Diagnosis for Myotonic Dystrophy Type 1 and Analysis of the Effect of the Disease on the Reproductive Outcome of the Affected Female Patients

Table 2

Clinical results of PGD cycles for couples with the female affected of DM1 at different centres.

	HUVR, Seville, Spain; (this work)	Shaare-Zedek; Medical Centre, Jerusalem	UCL Centre for PGD, London, UK	CHU Montpellier, France
Number of couples treated	22	21	13	17
Maternal age	33.2 ± 3.7	30.7 ± 5.2	32.8 ± 3.4	32.1 ± 3.2
Number of cycles performed	33	57	18	33
Number of cycles performed per couple	1.5 ± 0.7	2.71 ± 2.05	1.38 ± 0.51	1.94
Number of mature oocytes submitted to ICSI per cycle	8.7 ± 5.8	7.96 ± 6.6	9.82 ± 5.6	NA
% of oocytes fertilized	49.7%	70.2%	66.5%	NA
% of transfers	60.6%	61.4%	55.5%	42.4%
% of clinical pregnancies per cycle	15.5%	17.5%	22.2%	15.2%
% of clinical pregnancies per transfer	25%	28.57%	40.0%	35.7%
Number of pregnancies went to term	5	8	4	NA
Live birth rate per cycle	15.2%	14.0%	27.8%	NA
Live birth rate per transfer	25%	22.9%	50%	NA