miR-503 Is Involved in the Protective Effect of Phase II Enzyme Inducer (CPDT) in Diabetic Cardiomyopathy via Nrf2/ARE Signaling Pathway

Figure 3

The expression of miR-503, Nrf2, downstream medium, and apoptosis level in streptozotocin- (STZ-) induced diabetes and treatment rats; CR: control rats; DR: diabetes rats; TR: treatment rats. (a) The expression of miR-503. (b) The gene expression of Nrf2. (c) The protein expression of Nrf2 and downstream medium. (d) The apoptosis level. (e) The apoptosis level by TUNEL staining (×200). : compared with control rats, value < 0.05 was considered to be statistically significant; #: compared with diabetes rats, value < 0.05 was considered to be statistically significant.

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