Expression of Neurotrophin-3 and trkC following Focal Cerebral Ischemia in Adult Rat Brain with Treadmill Exercise

Figure 1

Expression profile of NT-3. (A) There are two forms of NT-3, dimer (40 kDa) and monomer (21 kDa). Exercise in the sham group increased immunoreactivities of the monomer. Exercise in ischemia increased the monomer in the contralateral hemisphere (contra). (B) In the ischemia-nonexercise group, expression of the NT-3 dimer protein decreased from postinfarct day 9 to postinfarct day 23 in the contralateral region. In the ipsilateral region, expression of NT-3 dimer protein was decreased at postinfarct day 9 and then increased at postinfarct day 23. However, in the ischemia-exercise group, expression of the NT-3 dimer protein was decreased at postinfarct day 16 and then increased at postinfarct day 23. (C) The expression of NT-3 dimer protein increased along with severities II and III in the ischemia-nonexercise group. However, expression of NT-3 dimer decreased in the ischemia-exercise group. (D) (a) Immunoreactivity decreased in the core of the infracted region. In contrast, staining increased around the ischemic area. (b) Exercise decreased this contrasting effect. (a’) and (b’) are magnificent figures of (a) and (b) each. ■ = 25 μm ().