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BioMed Research International
Volume 2017 (2017), Article ID 9251806, 12 pages
https://doi.org/10.1155/2017/9251806
Research Article

Preparation of P3HB4HB/(Gelatin + PVA) Composite Scaffolds by Coaxial Electrospinning and Its Biocompatibility Evaluation

1Guizhou Medical University, Guiyang 550004, China
2Department of Prosthodontics, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
3Department of Orthopaedics, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
4Center for Tissue Engineering and Stem Cells, Guizhou Medical University, Guiyang 550004, China
5Department of Orthopaedics, Massachusetts General Hospital, Boston, MA 02115, USA

Correspondence should be addressed to Yu-Feng Song; moc.621@codgnefuygnos

Received 18 March 2017; Revised 19 June 2017; Accepted 6 September 2017; Published 19 November 2017

Academic Editor: Willeke F. Daamen

Copyright © 2017 Min-Xian Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study was conducted to prepare coaxial electrospun scaffolds of P3HB4HB/(gelatin + PVA) with various concentration ratios with P3HB4HB as the core solution and gelatin + PVA mixture as the shell solution; the mass ratios of gelatin and PVA in each 10 mL shell mixture were 0.6 g : 0.2 g (Group A), 0.4 g : 0.4 g (Group B), and 0.2 g : 0.6 g (Group C). The results showed that the pore size, porosity, and cell proliferation rate of Group C were better than those of Groups A and B. The ascending order of the tensile strength and modulus of elasticity was Group A < Group B < Group C. The surface roughness was Group C > Group B > Group A. The osteogenic and chondrogenic-specific staining showed that Group C was stronger than Groups A and B. This study demonstrates that when the mass ratio of gelatin : PVA was 0.2 g : 0.6 g, a P3HB4HB/(gelatin + PVA) composite scaffold with a core-shell structure can be prepared, and the scaffold has good biocompatibility that it may be an ideal scaffold for tissue engineering.