Current Nucleic Acid Extraction Methods and Their Implications to Point-of-Care Diagnostics

Table 5

Summary of available devices used in nucleic acid extraction protocols.

Material	Molecule of affinity	Advantage	Disadvantage	Reference
(1) Spin columns	DNA, RNA	Fast; reproducible	Aerosols cross-contamination; infrastructure and equipment required	[49]
(2) Beads or magnetic beads	DNA, RNA	Simple to use; high automation potential; equipment-free process	Labor intensive	[78]
(3) Automation (liquid handling robots)	DNA, RNA	Precise manipulation of sample and reagents, reducing losses and cost	High cost	[79]
(4) Microfluidics and “lab-on-a-chip” cartridges	DNA, RNA	Sensitive and specific	Incompatibility of common NAE chemicals	[80]