Heterologous Secretory Expression and Characterization of Dimerized Bone Morphogenetic Protein 2 in Bacillus subtilis

Table 1

Comparison of different recombinant human proteins produced in Bacillus species.

Recombinant human proteins	Vector	Media	Yield	Species	Reference
Epidermal Growth Factor	pM2Veg	LB	7.0 mg/L	B. subtilis	[19]
Interferon-α2	pKTH68	Broth-starch Medium	0.5–1.0 mg/L	B. subtilis	[20]
Interleukin 3	pMA5 derivatives	2X YT, MXR, MSR	100 μg–100 mg/L	B. subtilis	[16]
Granulocyte Colony Stimulating Factor	pNWPH	2X L-MAL	96 mg/L	B. subtilis	[18]
Proinsulin	pSubP14	Mineral medium (MMG)	1000 mg/L	B. subtilis	[21]
BMP7	pBPT62	LBL	350 ng/L	B. subtilis	[15]
Interleukin 2	pNU211	3PY	120 mg/L	B. brevis	[17]
rhBMP2	pHT43	2X YT	5–9 mg/L	B. subtilis	Current study