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BioMed Research International
Volume 2017, Article ID 9351507, 7 pages
Review Article

Proteobacteria: A Common Factor in Human Diseases

Department of Internal Medicine, Gastroenterology Division, Policlinico “A. Gemelli” Hospital, Rome, Italy

Correspondence should be addressed to A. Gasbarrini; ti.ttacinu@inirrabsag.oinotna

Received 5 July 2017; Accepted 16 October 2017; Published 2 November 2017

Academic Editor: Filippo Canducci

Copyright © 2017 G. Rizzatti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Microbiota represents the entire microbial community present in the gut host. It serves several functions establishing a mutualistic relation with the host. Latest years have seen a burst in the number of studies focusing on this topic, in particular on intestinal diseases. In this scenario, Proteobacteria are one of the most abundant phyla, comprising several known human pathogens. This review highlights the latest findings on the role of Proteobacteria not only in intestinal but also in extraintestinal diseases. Indeed, an increasing amount of data identifies Proteobacteria as a possible microbial signature of disease. Several studies demonstrate an increased abundance of members belonging to this phylum in such conditions. Major evidences currently involve metabolic disorders and inflammatory bowel disease. However, more recent studies suggest a role also in lung diseases, such as asthma and chronic obstructive pulmonary disease, but evidences are still scant. Notably, all these conditions are sustained by various degree of inflammation, which thus represents a core aspect of Proteobacteria-related diseases.