Research Article
Immunogenicity and Cross Protection in Mice Afforded by Pandemic H1N1 Live Attenuated Influenza Vaccine Containing Wild-Type Nucleoprotein
Table 1
Protection of mice against challenge with H1N1 wild-type viruses following immunization with LAIV H1N1.
| | Vaccine | Challenge virus | | A/South Africa/3626/2013 (H1N1) | A/New York/61/15 (H1N1) | A/PR/8 7 : 1 rg (NP-SA) (H1N1) | | Number died/total | % maximum weight loss | Mean virus titer in lungs,
log10EID50/ml | Number died/total | % maximum weight loss | Mean virus titer in lungs,
log10EID50/ml | Number died/total | % maximum weight loss | Mean virus titer in lungs,
log10EID50/ml |
| | LAIV 6 : 2 | 0/6 | 18.3 | | 0/6 | 5.9 | | 0/6 | 9.0 | | | LAIV 5 : 3 | 0/6 | 2.8 | | 0/6 | 2.8 | | 0/6 | 3.3 | | | Control | 5/6 | 26.9 | | 6/6 | 13.8 | | 2/6 | 3.6 | |
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significant at .
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