Therapy Effects of Wogonin on Ovarian Cancer Cells

Figure 2

Combination effects of wogonin and MPP on cancer cell invasion and clonogenic survival in A2780 ovarian cancer cells. ((a) and (b)) Wogonin inhibits A2780 ovarian cancer cells migration. Representative images of wound scratch assay showing the effect of wogonin on cell migration. Graph showing the change of inhibition ratio for wound scratch rehealing. (c) Invasion assay. Representative images showing the effect of wogonin on cancer cell invasiveness. (d) Combined effects of wogonin and MPP on clonogenic survival of A2780 ovarian cancer cells. Representative images showing the surviving colonies. (e) Graphs showing the changes of clonogenic survival fraction. The error bars represent the standard error, versus control group and versus wogonin + MPP group, . (f) Western blot analysis showing the effects of wogonin and MPP on ER-α, VEGF, and p53 protein expression in A2780 ovarian cancer cells. β-Actin was included as a loading control. Data present average results from three independent experiments; SD means the standard deviation ().

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