Enhancement of Angiogenesis by Ultrasound-Targeted Microbubble Destruction Combined with Nuclear Localization Signaling Peptides in Canine Myocardial Infarction

Figure 6

Masson trichrome staining of the infarcted zone on day 28 after Ang-1 gene transfection. Representative photomicrographs show the fibrosis of infarcted myocardium (myocardium in red, fibrosis in blue, magnification 100x, scale bar = 100 μm). Compared with other groups, fibrosis of the infarct zone was obviously suppressed in group C, which was featured by less collagen fiber and formation of more normal myocardium. (a), (b), (c), (d), and (e) represented groups A, B, C, D, and E, respectively.

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