Patients Affected by Unmethylated O(6)-Methylguanine-DNA Methyltransferase Glioblastoma Undergoing Radiochemotherapy May Benefit from Moderately Dose-Escalated Radiotherapy

Table 1

Clinical (age = age at diagnosis, KPS = Karnofsky Performance Status), treatment (GTR = macroscopic gross total resection, B/STR = biopsy or subtotal tumor resection, dose RT = total dose for radiotherapy treatment, HDRT = 70 Gy, and SDRT = 59,4–60 Gy), and biological (MGTM) prognostic factors (Kaplan-Meier method, survival analysis).

		Number of patients	OS	value	PDFS	value
			Median (months)		Median (months)
Age	>50	100	12	0,09	9	0,30
	<50	17	17		9
KPS	100–80	106	14	0,001	9	0,018
	=70	11	7		4
Extent of surgery	GTR	32	22	0,02	12	0,005
	B/STR	85	11		7
MGMT status	Methylated	48	25	0,0001	15	0,001
	Unmethylated	69	11		7
RT DOSE	HDRT	45	14	0,22	10	0,12
	SDRT	72	12		7