Research Article

Patients Affected by Unmethylated O(6)-Methylguanine-DNA Methyltransferase Glioblastoma Undergoing Radiochemotherapy May Benefit from Moderately Dose-Escalated Radiotherapy

Table 2

(a) HDRT-TMZ and SDRT-TMZ patient’s characteristic in methylated group ()

HDRT patients ()SDRT patients ()Chi-square significance

KPS100–801232
=7004

Extent of resectionGRT610
B/SRT626

Age>50 ys1127
<50 ys19

Radiological responseComplete response69
Partial response36
Stable disease19
Progression disease212

Radionecrosis11

(b) HDRT-TMZ and SDRT-TMZ patient’s characteristic in unmethylated group ()

HDRT patients ()SDRT patients ()Chi-square significance

KPS100–803032
=7034

Extent of resectionGRT97
B/SRT2429

Age>50 ys2933
<50 ys43

Radiological responseComplete response73
Partial response72
Stable disease76
Progression disease1225

Radionecrosis10