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BioMed Research International
Volume 2017 (2017), Article ID 9547902, 6 pages
https://doi.org/10.1155/2017/9547902
Research Article

Association between NLPR1, NLPR3, and P2X7R Gene Polymorphisms with Partial Seizures

1Department of Pharmacy, The First People’s Hospital of Lianyungang, The Affiliated Hospital of Kangda College of Nanjing Medical University, Jiangsu, Lianyungang 222002, China
2Institute of Clinical Pharmacy & Pharmacology, Jining First People’s Hospital, Jining Medical University, Jining 272000, China
3Department of Pharmacy, Hunan Cancer Hospital, Central South University, Changsha 410011, China
4Department of Pharmacy, Second Xiangya Hospital, Central South University, Changsha 410010, China

Correspondence should be addressed to Pei Jiang

Received 5 January 2017; Accepted 6 April 2017; Published 19 April 2017

Academic Editor: Nobuo Kanazawa

Copyright © 2017 Haidong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. Clinical and experimental evidence has clarified that the inflammatory processes within the brain play a pivotal role in the pathophysiology of seizures and epilepsy. Inflammasomes and P2X7 purinergic receptor (P2X7R) are important mediators during the inflammatory process. Therefore, we investigated the possible association between partial seizures and inflammasomes NLPR1, NLRP3, and P2X7R gene polymorphisms in the present study. Method. A total of 163 patients and 201 health controls were enrolled in this study and polymorphisms of NLPR1, NLRP3, and P2X7R genes were detected using polymerase chain reaction- (PCR-) ligase detection reaction method. Result. The frequency of rs878329 (G>C) genotype with C (CG + CC) was significantly lower among patients with partial seizures relative to controls (OR = 2.033, 95% CI = 1.290–3.204, for GC + CC versus GG). Intriguingly, we found that the significant difference of rs878329 (G>C) genotype and allele frequency only existed among males (OR = 2.542, 95% CI = 1.344–4.810, for GC + CC versus GG), while there was no statistically significant difference among females. However, no significant results were presented for the genotype distributions of rs8079034, rs4612666, rs10754558, rs2027432, rs3751143, and rs208294 polymorphisms between patients and controls. Conclusion. Our study demonstrated the potentially significant role of NLRP1 rs878329 (G>C) in developing susceptibility to the partial seizures in a Chinese Han population.